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CHEMO-1


20ml per ampoule

(during chemotherapy) Intravenous 60ml into 500ml
5% - 10% glucose solution for 2 weeks


INDICATIONS:

CHEMOTHERAPY SUPPORT
deficiency body fluids
coronary heart disease
viral cardiac muscle inflammation
chronic pulmonary heart disease



INGREDIENTS

Radix Ginseng Rubra
Radix Ophiopogonis





RESEARCH

Clinical observation of CHEMO-1 injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer
Objective: To observe the efficacy of CHEMO-1 injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer (NSCLC).
Methods: 45 NSCLC patients with stages IIIb-IV were randomly divided into two groups: the treatment group (treated by chemotherapy combined with CHEMO-1 injection) and the control group (treated by chemotherapy only). The efficacy of the two groups was evaluated after 3 cycles of treatment.
Results: There was no significant difference between the two groups in the recent curative effects (P>0.05), while there were significant differences between them in Karnofsky score and weight (P<0.05). The treatment group was better than the control group in preventing leucopenia and decreased hemoglobin, and significant differences were found between them (P<0.05). The incidence of thrombocytopenia, nausea and vomiting, hepatic and renal dysfunction in the treatment group was lower than that in the control group, but no significant differences were found between them (P>0.05).
Conclusion: CHEMO-1 injection would not influence the efficacy of chemotherapy on advanced NSCLC patients, while it could improve the quality of life, increase the body weight of patients, alleviate adverse reactions of chemotherapy as myelosuppression so as to improve the tolerance of organism to chemotherapy.
THE CHINESE-GERMAN JOURNAL OF CLINICAL ONCOLOGY Volume 7, Number 2, 81-83, DOI: 10.1007/s10330-007-0157-6


Clinical Effect of CHEMO-1 on White Blood Cell
Objective: To observe the safety and effectiveness of CHEMO-1 Injection in increasing white blood cells (WBCs) and evaluate its value in application.
Method: 60 cancer patients under chemotherapy were randomly classified into two groups: 40 in Group One were treated by CHEMO-1 Injection and 20 in Group Two by Recombinant Human Granulocyte Colony Stimulating Factor Injection (rhG-CSF). A week before a chemotherapy period, 100ml of CHEMO-1 Injection was added to 250mL of 5% GS and intravenously dripped to each patient in Group One everyday for 15 days. Patients in Group Two were given routine blood tests during their chemotherapy. When WBC was<=3.0G/L,75μg rhG-CSF was hypodermically injected to the patients until WBC was>=I0.0G/L.
Result: WBC sincreased in all the patients in Group One, who finished their chemotherapy on schedule. WBCs also increased in all the patients in Group Two, but 12 of them had sharp pain all over their bodies. Conclusion: In terms of WBC increase, the effect of CHEMO-1 Injection is better than that of rhG-CSF, in that CHEMO-1 Injection presents a longer, safer, tenderer, and more effective result.
LIAONING JOURNAL OF TRADITIONAL CHINESE MEDICINE 2006 33(5) R285.6 R31 O64


Effects of CHEMO-1 injection on expression of TNF-α mRNA in peritoneal macrophages of scald mice
Objective: To explore the effect of CHEMO-1 injection (SI) on expression of TNF-α mRNA in peritoneal macrophages (pMΦs) of scald mice.
Methods:
BALB/c mice were inflicted with 11% of body surface area degree scald and injected intraperitoneally (ip) with SI daily for 5 days, and expression of TNF-α mRNA in pMΦs was determined by semi- quantitative RT- PCR.
Results: In scald mice, the expression of TNF-α mRNA in pMΦs increased significantly, but it was reduced obviously (P<0.01) after SI administration, while the livability was increased markedly (P<0.05).
Conclusions: For scald mice, the cause of death at early stage might be related to the high expression of TNF-α mRNA in pMΦs and the use of SI can decrease the death rate.
Chinese Medical Journal 2002;115(2):293-295

Herb-Drug interactions: In vivo and in vitro effect of CHEMO-1injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in Rats
Shenmai injection (SMI), a mixture of Radix Ginseng and Radix Ophiopogonis, is one of the most popular herbal medicinal products and is widely used for the treatment of coronary atherosclerotic cardiopathy and viral myocarditis. The purpose of this study was to investigate the effect of SMI, in vivo and in vitro, on the metabolic activities of hepatic cytochrome CYP450 3A1/2, 2C6, 2E1, and 1A2 in rats. After a single or multiple pretreatment with SMI, the rats were administrated intravenously a cocktail containing midazolam (1 mg/kg), diclofenac (0.5 mg/kg), theophylline (1 mg/kg), and chlorzoxazone (0.5 mg/kg) as probe substrates of rat CYP450 3A1/2, 2C6, 1A2, and 2E1, respectively. Single and multiple SMI pretreatment to rats resulted in a rise of 33.8 % (p < 0.01) and 25.6 % (p < 0.01) in AUC for midazolam, and an increase in AUC for diclofenac by 14.7 % (p < 0.05) and 31.2 % (p < 0.01), respectively. However, the pharmacokinetics of chlorzoxazone and theophylline in rats was not altered markedly. In rat liver microsomes, linear mixed-type inhibition of SMI against the enzyme activities of CYP3A1/2, CYP2C6, and CYP1A2 was shown with IC50 values of 3.3 %, 2.0 %, and 3.1 % and Ki values of 3.8 %, 1.5 %. and 1.9 %, respectively. These in vivo and in vitro results demonstrated that SMI had the potential to inhibit the activities of hepatic CYP3A1/2 and CYP2C6, but might not significantly affect CYP1A2 and CYP2E1-mediated metabolism in rats.
Planta Medica: natural products and medicinal plant research, 76 3: 245-250. 2009-09-11

 
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