Research on the effect of Yi Qi Bu Shen oral liquid on tumor-infiltrating lymphocytes in vitro
Ruan Yeping, Hu Xiumin, Liu Yunxia, Li Fanzhu. Research on the effect of Yi Qi Bu Shen oral liquid on tumor-infiltrating lymphocytes in vitro. Dang Dai Yi Xue. 2009, 15 (4): 136-138.
To study the effect of Yiqi Bushen oral liquid YQBS on tumor-infiltrating lymphocytes TIL in vitro and its related immunological mechanism. Separation of T-lymphocyte by discontinuous density gradient centrifugation was used to observe the impaction of YQBS on survival of TIL. YQBS could prolong survival time of TIL significantly and enhanced the killing activity of autologous tumor cells and K562 cells. Moreover, the cell smear and electron microscopy analysis showed that TIL growth increased significantly by culturing about one week. YQBS could increase the growth and the activity of TIL. Notably the mechanism of anti-tumor effects of YQBS might be related to the strengthened immune function of mice.
Clinical Observation of Yiqi Bushen Oral Liquid to the Patients with Carcinoma of Large Intestine’s Metastasis and Relapse After Operation
Liu Yun-xia, Jiang Shen-jun, Kuang Tang-hong, Yao Yong-wei, Yang Jie-wen. Clinical Observation of Yiqi Bushen Oral Liquid to the Patients with Carcinoma of Large Intestine’s Metastasis and Relapse After Operation. Zhong Hua Zhong Yi Yao Xue Kan. 2007, 25 (5): 1072-1073.
To investigate both the therapeutic effect of Yiqi Bushen oral liquid on patients with carcinoma of large intestine metastasis after operation and its impact on quality of life, peripheral blood flow, and immune function. 54 patients with carcinoma of the large intestine after operation are divided into two groups randomly. In the therapeutic group, we use Yiqi Bushen oral liquid combined with chemotherapy to treat 33 patients, and in the control group, used only chemotherapy to treat 21 patients. The metastatic rate of the therapeutic group is much lower than the control group (P<0.05). Compared with the control group, the therapeutic group can improve the Kamofsky score, body weight, and peripheral blood flow. (P <0.01). Yiqi Bushen oral liquid has the good effect to resist metastasis and relapse of patients after operation of carcinoma of the large intestine. It additionally has effect on sensitization, attenuation, and quality of life.
An Experimental Study on Anti- tumor Effects of Yiqi Bushen Liquid in Vitro
Ruan Ye-ping, Hu Xiu-min. An Experimental Study on Anti- tumor Effects of Yiqi Bushen Liquid in Vitro. Zhong Hua Zhong Yi Yao Xue Kan. 2008, 26 (11): 2445-2446.
To investigate the anti-tumor effects of Yiqi Bushen liquid on hepatocarcinoma cells, SMMC - 27721, and lung carcinoma cells, A-549 in vitro. Viable cells count and MTT staining assay were used to assess the anti-tumor effects of Yiqi Bushen liquid on the two kind cells. Yiqi Bushen liquid had inhibitory action on growth curve of SMMC27721 and A549 cells. The IC50 of the two cells were 1.02mg/mL and 0.73mg/mL respectively. It also inhibited colony formation in both cell lines. The highest inhibitory rates of Yiqibushen liquid against SMMC27721 and A549 cells were 78.48% and 89.17% respectively. Yiqi Bushen liquid has strong anti -tumor effects in vitro.
Clinical Observation on 28 Cases of the Metabasis of Stomach Cancer after Operation Treated by Yiqi Bushen Oral Liquid: and Chemotherapy
Liu Yunxia, Jiang Shenjun, Kuang Tanghong, Yao Yongwei, Yang Jiewen, Wang Yiqing. Clinical Observation on 28 Cases of the Metabasis of Stomach Cancer after Operation Treated by Yiqi Bushen Oral Liquid: and Chemotherapy. Zhong Yi Za Zhi. 2008; 49 (2): 128-130.
To study the effect of Yiqi Bushen oral liquid and chemotherapy on the metastasis of stomach cancer after operation. Methods The 47 patients of stomach cancer after operation spleen and kidney deficiency syndrome were randomized into treatment a group (n=28) or control group (n=19). The control group was treated simply by chemotherapy and the treatment group by chemotherapy and Yiqi Bushen Oral Liquid. Condition of relapse and metastasis, quality of life, peripheral blood flow and immune function were observed 12 months later. The relapse and metastatic rate of the treatment group was remarkably lower than that of the control group (P<0.05). The Karnofsky score, peripheral blood and immune function were all remarkably improved in comparison with the control group (P<0.01 or P<0.05). Yiqi Bushen oral liquid, combined with chemotherapy, has a good function in resisting the metastasis of stomach cancer after operation, increasing chemosensitivity, decreasing adverse reactions, improving quality of life, and improving immune function of patients.