BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells
Lee CM, Su YH, Huynh TT, Lee WH, Chiou JF, Lin YK, Hsiao M, Wu CH, Lin YF, Wu AT, Yeh CT. Evid Based Complement Alternat Med. 2013;2013:258425. doi: 10.1155/2013/258425. Epub 2013 Jun 26).
Pterostilbene (PT) extracted from blueberries dose-dependently reduced the enrichment of CD133(+) Mahlavu cells upon irradiation; PT treatment also prevented tumour sphere formation, reduced stemness gene expression, and suppressed invasion and migration abilities as well as increasing apoptosis of CD133(+) Mahlavu CSCs.
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit.
Mak KK, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. doi: 10.1002/mnfr.201200549. Epub 2013 Mar 15.
PT effectively suppresses the generation of CSCs and metastatic potential under the influence of M2 TAMs via modulating EMT associated signalling pathways, specifically NF-κB/miR488 circuit. Thus, PT could be an ideal anti-CSC agent in clinical settings