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ARTEMISUNATE

RESEARCH

Inhibition of Artemisunate on Invasion of Human Colon Cancer Line SW620

Source:
Fan Y, Zhang Y-l, Yao G-t, Li Y-k. Inhibition of Artemisunate on Invasion of Human Colon Cancer Line SW620. Shi Zhen Guo Yi Guo Yao. 2008, 19(7): 1740-1741.

Objective:
To study the effects and mechanism of Artemisunate on human colon cancer.

Methods:
After colon cancer SW620 cells were treated with different doses of Artemisunate, the growth of anchorage independence of cancer cells was studied in soft agar colony formation, and invasion ability was determined by Boyden chamber, and the protein level of intercellular adhesion molecule-1 (ICAM-1) was detected by Western blot assay.

Results:
Artemisunate could significantly inhibit both invasion ability and anchorage independence growth in a dose-dependent manner. The level of protein of ICAM-1 was down-regulated as compared with control group.

Conclusion:
Artemisunate can inhibit invasion of colon carcinoma cell line SW620 through down-regulating ICAM-1 expression.

 
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