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ENT-CLERODANE DITERPENOIDS


INGREDIENTS
Ent-clerodane diterpenoids isolated from the whole plant of Scutellaria
barbata D. Don.





RESEARCH

Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.
Dai, S.J., Sun, J.Y., Ren, Y., Liu, K. & Shen, L. Bioactive ent-clerodane diterpenoids from Scutellaria barbata. Planta Med. 2007 Sep;73(11) Pp.1217-20. Epub 2007 Aug 31.

Two new ent-clerodane diterpenoids have been isolated from Scutellaria barbata, and their structures were established by detailed spectroscopic analyses as (13R)-6agr,7β-dihydroxy-8β,13-epoxy-11β-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1) and (11E)-6agr-acetoxy-7β,8β-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer cell lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 2.5-6.6 μM.
Qu, G-W., Yue, X-D., Li, G-S., Yu, Q-Y. & Dai, S-J. Two new cytotoxic ent-clerodane diterpenoids from Scutellaria barbata. Journal of Asian Natural Products Research, Volume 12, Issue 10 October 2010. Pp. 859-64. DOI: 10.1080/10286020.2010.507546

Four new ent-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1 - 7.2 μM.
Dai, S-J., Sun, J-Y., Ren, Y., Liu, K. & Shen, L. Bioactive ent-Clerodane Diterpenoids from Scutellaria barbata. Planta Med 2007; 73(11) Pp. 1217-20. DOI: 10.1055/s-2007-990215
 
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