Curcuma phaeocaulis valeton
Experimental study on inhibiting angiogenesis in mice Sarcoma (S-180) by injections of three traditional Chinese herbs
OBJECTIVE: To investigate the effect of inhibiting angiogenesis by injections of three traditoinal Chinese herbs (Oxy-matrine, curcuma phaeocaulis valeton, coix lacryma-jobi).
METHODS The tumour inhibitory rate and the vascular density were tested in animal tumour model with experimental treatment. The expression of VEGF and bFGF were measured by immunistological methods.
RESULTS: When the high dose were used, the tumour inhibitory rate of the three herbs groups(Oxymatrine, curcuma phaeocaulis valeton, coix lacryma-jobi) were 31.36% , 46.68% and 46.21%; the vascular density of S180 sarcoma were lower than that in the control group and the expression of VEGF and bFGF were down-regulated.
CONCLUSIONS: The three herbs have inhibitory effect on S180 sarcoma and strong inhibitory effects on angiogenesis. Its mechanism may be associated with the down-regulating of VEGF and bFGF expression.
Kong, Q-Z., Huang, D-S., Huang, T. et al. Chinese Journal of Hospital Pharmacy 2003-11. DOI: CNKI:SUN:ZGYZ.0.2003-11-002